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Ozone causes depressive-like response through PI3K/Akt/GSK3β pathway modulating synaptic plasticity in young rats

发布时间:2023-10-20   浏览次数:0

Cao Q, Zou L, Fan Z, Yan Y, Qi C, Wu B, Song B. Ozone causes depressive-like response through PI3K/Akt/GSK3β pathway modulating synaptic plasticity in young rats. Ecotoxicol Environ Saf. 2022;246:114171. doi: 10.1016/j.ecoenv.2022.114171.

 202210月73882必赢网页版宋波团队在《Ecotoxicology and Environmental Safety》(IF7.129)上发表了题为“Ozone causes depressive-like response through PI3K/Akt/GSK3β pathway modulating synaptic plasticity in young rats”的研究论文,揭示了出生早期暴露于臭氧(O3)可损伤海马神经元突触可塑性和出现抑郁样行为,该作用可能与O3暴露通过miR-221-3p靶向调控PIK3R1介导PI3K/Akt/GSK3β信号通路的改变有关。该期刊为中科院期刊分区毒理学一区、环境科学二区杂志。该论文第一作者为73882必赢网页版劳动卫生与环境卫生学教研室2020级硕士研究生曹琦。

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