杨瑞馥，博士, 研究员，军事科学院军事医学研究院微生物流行病研究所，国家自然科学基金杰出青年基金获得者。学术兼职：中国微生物学会组织工作委员会主任委员，中国营养学会益生菌益生元与健康专业委员会主任委员；军委科技委微生物学专业委员会主任委员；国家卫健委食品安全风险评估委员会委员；第二届食品安全国家标准审评委员会微生物检验方法与规程专业委员会 主任；中国卫生标准委员会传染病标准专业委员会委员等，《微生物学学报》、《人兽共患病学报》、《中华预防医学杂志》和《Zoonoses》副主编。获国家科技发明二等奖1项，并已成功转化。在New England Journal of Medicine, Science, Nature Genetics, Cell Metabolism, Nat Com., PNAS等杂志发表学术SCI论文200余篇，被引29，000余次，H因子74（Google Scholar）；获得国家食品药品监督管理局医疗器械注册证15项。

研究方向：

主要从事病原基因组学、进化、溯源与致病机制、检验新技术和人体微生物组与健康的研究。

主要承担的课题：

1. 国家自然基金重大项目（资助号32394054），项目名称：优良食品益生菌选育的生物学基础；具体承担项目：下一代益生菌定向选育的生物学基础；资助400万；执行期：2024.1-2028.1

2.国家“病原学与防疫技术体系研究”重点专项（资助号：2022YFC2303500）：高致病性病原体活体示踪及与宿主相互作用的研究；资助：1800万，执行期：2022.10-2024.10.

近期发表的代表性论文：

1.  Zhao Y, Wang T, Liu Z, Ke Y, Li R, Chen H, You Y, Wu G, Cao S, Du Z, Bai F, Yang R. Single-cell transcriptomics of immune cells in lymph nodes reveals their composition and alterations in functional dynamics during the early stages of bubonic plague. Sci China Life Sci, 2023, 66(1): 110-126.

2.  Yang L, Wang Z, Wang L, Vrancken B, Wang R, Wei Y, Rader B, Wu CH, Chen Y, Wu P, Li B, Lin Q, Dong L, Cui Y, Shi M, Brownstein JS, Stenseth NC, Yang R, Tian H. Association of vaccination, international travel, public health and social measures with lineage dynamics of SARS-CoV-2. Proc Natl Acad Sci U S A, 2023, 120(33): e2305403120.

3.  Chang Y, Huang Z, Hou F, Liu Y, Wang L, Wang Z, Sun Y, Pan Z, Tan Y, Ding L, Gao H, Yang R, Bi Y. Parvimonas micra activates the Ras/ERK/c-Fos pathway by upregulating miR-218-5p to promote colorectal cancer progression. J Exp Clin Cancer Res, 2023, 42(1): 13.

4.  Yang C, Li Y, Jiang M, Wang L, Jiang Y, Hu L, Shi X, He L, Cai R, Wu S, Qiu Y, Lu L, Zuo L, Chen Q, Wu Y, Martinez-Urtaza J, Wan C, Yang R, Cui Y, Hu Q. Outbreak dynamics of foodborne pathogen Vibrio parahaemolyticus over a seventeen year period implies hidden reservoirs. Nat Microbiol, 2022, 7(8): 1221-1229.

5.  Pan Z, Hu Y, Huang Z, Han N, Li Y, Zhuang X, Yin J, Peng H, Gao Q, Zhang W, Huang Y, Cui Y, Bi Y, Xu ZZ, Yang R. Alterations in gut microbiota and metabolites associated with altitude-induced cardiac hypertrophy in rats during hypobaric hypoxia challenge. Sci China Life Sci, 2022.

6.  Cao S, Jiao Y, Jiang W, Wu Y, Qin S, Ren Y, You Y, Tan Y, Guo X, Chen H, Zhang Y, Wu G, Wang T, Zhou Y, Song Y, Cui Y, Shao F, Yang R, Du Z. Subversion of GBP-mediated host defense by E3 ligases acquired during Yersinia pestis evolution. Nature communications, 2022, 13(1): 4526.

7.  Zhao Y, Li Y, Zhang P, Yan Z, Zhou Y, Du Y, Qu C, Song Y, Zhou D, Qu S, Yang R. Cell-based fluorescent microsphere incorporated with carbon dots as a sensitive immunosensor for the rapid detection of Escherichia coli O157 in milk. Biosens Bioelectron, 2021, 179: 113057.

8.  Zhao Y, Zhang P, Wang J, Zhou L, Yang R. A novel electro-driven immunochromatography assay based on upconversion nanoparticles for rapid pathogen detection. Biosens Bioelectron, 2020, 152: 112037.

9.  Tian H, Liu Y, Li Y, Wu CH, Chen B, Kraemer MUG, Li B, Cai J, Xu B, Yang Q, Wang B, Yang P, Cui Y, Song Y, Zheng P, Wang Q, Bjornstad ON, Yang R, Grenfell BT, Pybus OG, Dye C. An investigation of transmission control measures during the first 50 days of the COVID-19 epidemic in China. Science, 2020, 368(6491): 638-642.

10. Cui Y, Schmid BV, Cao H, Dai X, Du Z, Ryan Easterday W, Fang H, Guo C, Huang S, Liu W, Qi Z, Song Y, Tian H, Wang M, Wu Y, Xu B, Yang C, Yang J, Yang X, Zhang Q, Jakobsen KS, Zhang Y, Stenseth NC, Yang R. Evolutionary selection of biofilm-mediated extended phenotypes in Yersinia pestis in response to a fluctuating environment. Nature communications, 2020, 11(1): 281.

11.Yuan J, Chen C, Cui J, Lu J, Yan C, Wei X, Zhao X, Li N, Li S, Xue G, Cheng W, Li B, Li H, Lin W, Tian C, Zhao J, Han J, An D, Zhang Q, Wei H, Zheng M, Ma X, Li W, Chen X, Zhang Z, Zeng H, Ying S, Wu J, Yang R, Liu D. Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae. Cell Metab, 2019, 30(4): 675-688 e677.

12. Xu L, Stige LC, Leirs H, Neerinckx S, Gage KL, Yang R, Liu Q, Bramanti B, Dean KR, Tang H, Sun Z, Stenseth NC, Zhang Z. Historical and genomic data reveal the influencing factors on global transmission velocity of plague during the Third Pandemic. Proc Natl Acad Sci U S A, 2019, 116(24): 11833-11838.

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