蔡文通，博士，副研究员，中国科学院深圳先进技术研究院；一直从事细菌致病机制与宿主免疫机理研究。近五年来，搭建了功能基因组-转录组-蛋白质组-单细胞组的多组学研究平台，构建了细菌与肠道类器官互作的研究模型；揭示了致病性大肠杆菌与宿主互作的新分子机制2种和病原菌致病的共性新机制1种；相关成果以第一作者或通讯作者（含共同）发表于mBio、PLoS Pathogens、Molecular Microbiology、Journal of Bacteriology（亮点文章）等权威学术期刊；主持国家自然科学基金和科技部重点研发计划项目任务3项；以第一完成人，获得发明专利2项。在美国留学期间，获得Plant Science Institute Fellowship，Research Excellence Award等奖项。任中国畜牧兽医学会动物传染病学分会青年学者专业组委员。担任Cellular Microbiology、Journal of Bacteriology、Journal of Applied Microbiology等多家专业期刊审稿人。

研究方向：

1.病原菌致病机制与宿主免疫机理

2.基于肠道微生物组的活菌药物研究与应用

3. 新型微生物检测技术的开发与优化

主要承担的课题：

1.2020.1-2022.12 国家自然科学基金青年科学基金项目“响应调控蛋白AbsR促进禽致病性大肠杆菌体内适应性的分子机制”，31902242，主持人；

2.2018.7-2021.6 科技部十三五重点研发计划“重要人畜共患食源性病原微生物在动物养殖和屠宰过程中的风险监测和防控技术研究”项目，2018YFD0500501，子课题负责人；

3.2018.7-2021.6 科技部十三五重点研发计划“生物安全”非公开项目，子课题负责人；

近期发表的代表性论文：

1. Zhao, D., Zhang, H., Zhang, X., Jiang, F., Li, Y., Cai, W. *, & Li, G*. (2023). The virulence regulator AbsR in avian pathogenic Escherichia coli has pleiotropic effects on bacterial physiology. Journal of Integrative Agriculture. 10.1016/j.jia.2023.07.035

2. Jiang F, Yang Y, Mao Z, Cai W*, Li G*. ArcA positively regulates the expression of virulence genes and contributes to virulence of porcine Shiga toxin-producing enterotoxigenic Escherichia coli. Microbiol Spectr. 2023 Dec 12;11(6):e0152523. doi: 10.1128/spectrum.01525-23.

3.Yang D, Yang Y, Qiao P, Jiang F, Zhang X, Zhao Z, Cai T, Li G*, Cai W*. 2023. Genomic island-encoded histidine kinase and response regulator coordinate mannose utilization with virulence in enterohemorrhagic Escherichia coli. mBio doi: 10.1128/mbio.03152-22

4.Gu H, Cai X, Zhang X, Luo J, Zhang X, Cai W*, Li G*. 2021. A previously uncharacterized two-component signaling system in uropathogenic Escherichia coli coordinates protection against host-derived oxidative stress with activation of hemolysin-mediated host cell pyroptosis. PLoS Pathog doi:10.1371/journal.ppat.1010005.

5.Yang D, Jiang F, Huang X, Li G*, Cai W*. 2021. Transcriptomic and Metabolomic Profiling Reveals That KguR Broadly Impacts the Physiology of Uropathogenic Escherichia coli Under in vivo Relevant Conditions. Frontiers in Microbiol, https://doi.org/10.3389/fmicb.2021.793391

6. Zhang X, Huang D, Zhao Z, Cai X, Cai W*, Li G*. 2021. Bis-molybdopterin guanine dinucleotide modulates hemolysin expression under anaerobiosis and contributes to fitness in vivo in uropathogenic Escherichia coli. Molecular Microbiology doi:10.1111/mmi.14809.

7. Li H, Hu S, Yan X, Yang Y, Liu W, Bu Z, Li G*, Cai W*. 2021. An extracytoplasmic function (ECF) sigma/anti-sigma factor system regulates hypochlorous acid resistance and impacts expression of the type IV secretion system in Brucella melitensis. J of Bacteriol doi:10.1128/JB.00127-21. (Highlight article)

8. Chen X, Liu W, Li H, Yan S, Jiang F, Cai W*, Li G*. 2021. Whole genome sequencing analysis of avian pathogenic Escherichia coli from China. Vet Microbiol 259:109158.

9. Liu YY, Li HM, Chen XH, Tong PP, Zhang Y, Zhu MY, Su ZQ, Yao G, Li G*, Cai W*. 2021. Characterization of Shiga toxin-producing Escherichia coli isolated from Cattle and Sheep in Xinjiang province, China, using whole-genome sequencing. Transboundary and Emerging Diseases doi:10.1111/tbed.13999.

10.Yan X, Hu S, Yang Y, Xu D, Li H, Liu W, He X, Li G, Cai W*, Bu Z*. 2020. The Twin-Arginine Translocation System Is Important for Stress Resistance and Virulence of Brucella melitensis. Infection and Immunity 88.

联系方式：

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